Differential neuropsychological profiles in Parkinsonian patients with or without vascular lesions
Identifieur interne : 001D49 ( Main/Exploration ); précédent : 001D48; suivant : 001D50Differential neuropsychological profiles in Parkinsonian patients with or without vascular lesions
Auteurs : Gabriella Santangelo [Italie] ; Carmine Vitale [Italie] ; Luigi Trojano [Italie] ; Danilo De Gaspari [Italie] ; Leonilda Bilo [Italie] ; Angelo Antonini [Italie] ; Paolo Barone [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-01-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Cerebrovascular Disorders (complications), Cerebrovascular Disorders (psychology), Cerebrovascular Disorders (radionuclide imaging), Cognition Disorders (etiology), Cognition Disorders (radionuclide imaging), Denervation, Executive Function (physiology), Female, Frontal Lobe (pathology), Frontal Lobe (radionuclide imaging), Frontal lobe, Human, Humans, Magnetic Resonance Imaging (methods), Male, Memory (physiology), Mental Status Schedule, Middle Aged, Nervous system diseases, Neurologic Examination (methods), Neuropsychological Tests, Parkinson disease, Parkinson's disease, Parkinsonian Disorders (complications), Parkinsonian Disorders (psychology), Parkinsonian Disorders (radionuclide imaging), Statistics, Nonparametric, Tomography, Emission-Computed, Single-Photon (methods), Tropanes (diagnostic use), cerebrovascular lesions, cognitive functions, dopaminergic denervation, frontal lobe functions.
- MESH :
- chemical , diagnostic use : Tropanes.
- complications : Cerebrovascular Disorders, Parkinsonian Disorders.
- etiology : Cognition Disorders.
- methods : Magnetic Resonance Imaging, Neurologic Examination, Tomography, Emission-Computed, Single-Photon.
- pathology : Frontal Lobe.
- physiology : Executive Function, Memory.
- psychology : Cerebrovascular Disorders, Parkinsonian Disorders.
- radionuclide imaging : Cerebrovascular Disorders, Cognition Disorders, Frontal Lobe, Parkinsonian Disorders.
- Aged, Female, Humans, Male, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Statistics, Nonparametric.
Abstract
The purpose of this study is to compare the neuropsychological profile of patients affected by parkinsonism and vascular lesions to that in patients with PD alone (PD) and to evaluate whether the brain vascular lesion load is associated with neuropsychological variables. Thirty‐six nondemented patients with parkinsonism were divided into 3 groups of 12 patients each, according to both clinical history and the presence of brain vascular lesions and/or dopaminergic denervation as revealed by magnetic resonance and dopamine transporter imaging, respectively. The first group had vascular lesions without dopaminergic denervation (VP group); the second group had vascular lesions and dopaminergic denervation (DD) (VP+DD group); and the third group consisted of patients with dopaminergic denervation (PD group) without vascular lesions. All patients underwent neurological and neuropsychological assessments. The groups differed in disease duration, age at onset, and cerebrovascular risk factors. The VP and VP+DD groups performed worse than the PD group on frontal/executive tasks. Regardless of the presence of dopaminergic denervation, cerebrovascular lesions in hemispheric white matter, basal ganglia, and cerebellum have an important effect in determining early onset and severity of cognitive impairment in patients with parkinsonism. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22893
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-01-15">2010-01-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="50">50</biblScope><biblScope unit="page" to="56">56</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">CA49CDA1F1BC87C5782A64365503D6CC51681E1A</idno><idno type="DOI">10.1002/mds.22893</idno><idno type="ArticleID">MDS22893</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cerebrovascular Disorders (complications)</term><term>Cerebrovascular Disorders (psychology)</term><term>Cerebrovascular Disorders (radionuclide imaging)</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (radionuclide imaging)</term><term>Denervation</term><term>Executive Function (physiology)</term><term>Female</term><term>Frontal Lobe (pathology)</term><term>Frontal Lobe (radionuclide imaging)</term><term>Frontal lobe</term><term>Human</term><term>Humans</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Memory (physiology)</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Neurologic Examination (methods)</term><term>Neuropsychological Tests</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Parkinsonian Disorders (complications)</term><term>Parkinsonian Disorders (psychology)</term><term>Parkinsonian Disorders (radionuclide imaging)</term><term>Statistics, Nonparametric</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term><term>Tropanes (diagnostic use)</term><term>cerebrovascular lesions</term><term>cognitive functions</term><term>dopaminergic denervation</term><term>frontal lobe functions</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Tropanes</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Cerebrovascular Disorders</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term><term>Neurologic Examination</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Frontal Lobe</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Executive Function</term><term>Memory</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Cerebrovascular Disorders</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Cerebrovascular Disorders</term><term>Cognition Disorders</term><term>Frontal Lobe</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Enervation</term><term>Homme</term><term>Lobe frontal</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of this study is to compare the neuropsychological profile of patients affected by parkinsonism and vascular lesions to that in patients with PD alone (PD) and to evaluate whether the brain vascular lesion load is associated with neuropsychological variables. Thirty‐six nondemented patients with parkinsonism were divided into 3 groups of 12 patients each, according to both clinical history and the presence of brain vascular lesions and/or dopaminergic denervation as revealed by magnetic resonance and dopamine transporter imaging, respectively. The first group had vascular lesions without dopaminergic denervation (VP group); the second group had vascular lesions and dopaminergic denervation (DD) (VP+DD group); and the third group consisted of patients with dopaminergic denervation (PD group) without vascular lesions. All patients underwent neurological and neuropsychological assessments. The groups differed in disease duration, age at onset, and cerebrovascular risk factors. The VP and VP+DD groups performed worse than the PD group on frontal/executive tasks. Regardless of the presence of dopaminergic denervation, cerebrovascular lesions in hemispheric white matter, basal ganglia, and cerebellum have an important effect in determining early onset and severity of cognitive impairment in patients with parkinsonism. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Santangelo, Gabriella" sort="Santangelo, Gabriella" uniqKey="Santangelo G" first="Gabriella" last="Santangelo">Gabriella Santangelo</name></noRegion><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><name sortKey="Bilo, Leonilda" sort="Bilo, Leonilda" uniqKey="Bilo L" first="Leonilda" last="Bilo">Leonilda Bilo</name><name sortKey="De Gaspari, Danilo" sort="De Gaspari, Danilo" uniqKey="De Gaspari D" first="Danilo" last="De Gaspari">Danilo De Gaspari</name><name sortKey="Santangelo, Gabriella" sort="Santangelo, Gabriella" uniqKey="Santangelo G" first="Gabriella" last="Santangelo">Gabriella Santangelo</name><name sortKey="Santangelo, Gabriella" sort="Santangelo, Gabriella" uniqKey="Santangelo G" first="Gabriella" last="Santangelo">Gabriella Santangelo</name><name sortKey="Trojano, Luigi" sort="Trojano, Luigi" uniqKey="Trojano L" first="Luigi" last="Trojano">Luigi Trojano</name><name sortKey="Vitale, Carmine" sort="Vitale, Carmine" uniqKey="Vitale C" first="Carmine" last="Vitale">Carmine Vitale</name><name sortKey="Vitale, Carmine" sort="Vitale, Carmine" uniqKey="Vitale C" first="Carmine" last="Vitale">Carmine Vitale</name><name sortKey="Vitale, Carmine" sort="Vitale, Carmine" uniqKey="Vitale C" first="Carmine" last="Vitale">Carmine Vitale</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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